Potassium benzylpenicillin

Potassium benzylpenicillin - Names and Identifiers

Name	Benzylpenicillin potassium
Synonyms	R-Pen Pen-G Forpen Pentid Falapen tabilin Tabilin Pentids Hylenta Monopen Hyasorb Orpeneed Liquapen Cosmopen M-cillin Novopen-G Cristapen Dixocillin Eskacillin Truxcillin Hipercilina Sugracillin 4-Thia-1-azabicyclo PENICILLIN G K-SALT Unilab Penicillin G PENICILLIN G POTASSIUM Penicillin G potassium Benzylpenicillin potassium potassium benzylpenicillin PENICILLIN G POTASSIUM SALT Potassium benzylpenicillinate Benzylpenicillinic acid potassium salt Monopotassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1 -azabicyclo potassium 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid potassium [2S-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate potassium [2s-(2alpha,5alpha,6beta)]-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-, [2S-(2alpha,5alpha,6beta)]-, monopotassium salt
CAS	113-98-4
EINECS	204-038-0
InChI	InChI=1/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/t11-,12+,14-;/m1./s1
InChIKey	IYNDLOXRXUOGIU-LQDWTQKMSA-M

Potassium benzylpenicillin - Physico-chemical Properties

Molecular Formula	C16H17KN2O4S
Molar Mass	372.48
Melting Point	214-217 C
Specific Rotation(α)	D22 +285° (c = 0.748 in water)
Water Solubility	Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform.
Solubility	H2O: 100mg/mL
Appearance	Powder
Color	Needles from butanol (aq)
Merck	14,7094
BRN	3832841
PH	pH (10g/L, 25℃) : 5.0～7.5
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Stability	Hygroscopic
Refractive Index	294 ° (C=1, H2O)
MDL	MFCD00036193
Use	Belongs to high efficiency and low toxicity antibiotics

Potassium benzylpenicillin - Risk and Safety

Risk Codes	R42/43 - May cause sensitization by inhalation and skin contact. R34 - Causes burns R11 - Highly Flammable
Safety Description	S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S60 - This material and its container must be disposed of as hazardous waste. S37 - Wear suitable gloves. S24 - Avoid contact with skin. S22 - Do not breathe dust.
WGK Germany	2
RTECS	XH9700000
FLUKA BRAND F CODES	10-23
TSCA	Yes
HS Code	29411000
Toxicity	LD50 oral in rabbit: 5848mg/kg

Potassium benzylpenicillin - Upstream Downstream Industry

Raw Materials	Phenylacetic acid Phenylacetic acid n-Butyl acetate 1-Butanol Dextrose Anhydrate Potassium carbonate Potassium carbonate Ethyl Alcohol 1-Butanol
Downstream Products	6-Aminopenicillanic acid procaine penicillin

Potassium benzylpenicillin - Standard

Authoritative Data Verified Data

(25,5R,6R)-3, 3-dimethyl-6-(2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid potassium salt. Calculated as dry product, including C16H17KN204S shall not be less than 96.0%.

Last Update：2024-01-02 23:10:35

Potassium benzylpenicillin - Trait

Authoritative Data Verified Data

This product is a white crystalline powder; Odorless or slightly specific odor; Hygroscopicity; Rapid failure when exposed to acid, alkali or oxidant, and easy failure when placed in aqueous solution at room temperature.
This product is easily soluble in water, slightly soluble in ethanol, insoluble in fatty oil or liquid paraffin.

Last Update：2022-01-01 13:33:02

Potassium benzylpenicillin - Differential diagnosis

Authoritative Data Verified Data

in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 223).
This product shows the reaction of potassium salt identification (1) (General rule 0301).

Last Update：2022-01-01 13:33:02

Potassium benzylpenicillin - Exam

Authoritative Data Verified Data

absorbance

take this product, precision weighing, adding water to dissolve and quantitatively dilute the solution containing 0401 mg per lml, according to UV-visible spectrophotometry (general) determination, in the wavelength of 280nm and 325nm, the absorbance should not be greater than 0.10; In the wavelength of 264nm, there is maximum absorption, absorbance should be 0.80~0.88.

visible foreign body

take 5 parts of this product, each 0.625g, plus particle inspection water dissolution, inspection according to law (General 0904), should comply with the provisions. (For aseptic dispensing)

insoluble particles

Take 3 parts of this product, and make a solution containing 50mg per lml of water for particle inspection, and check it according to law (General rule 0903). In each lg sample, particles containing 10um and more than 10um shall not exceed 6000 particles, and particles containing 25um and more than 25um shall not exceed 600 particles. (For aseptic dispensing)

crystallinity, pH, clarity and color of the solution, related substances, penicillin polymer, loss on drying, bacterial endotoxin (for injection) and sterility (for aseptic dispensing)

According to the method under the item of penicillin sodium inspection, should comply with the provisions.

Last Update：2022-01-01 13:33:03

Potassium benzylpenicillin - Content determination

Authoritative Data Verified Data

take this product, according to the method under the item of penicillin sodium, according to the external standard method to calculate the peak area, the result is multiplied by 1.1136, that is, the content of C16H17KN2O4S in the sample.

Last Update：2022-01-01 13:33:03

Potassium benzylpenicillin - Category

Authoritative Data Verified Data

B-lactam antibiotics, penicillins.

Last Update：2022-01-01 13:33:04

Potassium benzylpenicillin - Storage

Authoritative Data Verified Data

sealed and stored in a cool, dark and dry place.

Last Update：2022-01-01 13:33:04

Potassium benzylpenicillin - Penicillin potassium for injection

Authoritative Data Verified Data

This product is a crystalline sterile powder of penicillin potassium. The content of Cl6H17KN204S shall not be less than 96.0% based on the dry product; The content of C16H17KN204S shall be 95.0% ~ 115.0% of the label amount based on the average loading.

trait

This product is a white crystalline powder.

Post

take this product, according to penicillin potassium under the identification test, showed the same results.

examination

the clarity and color of the solution should be checked according to the method under the item of penicillin sodium for injection, and should comply with the regulations.
the content under the item of difference in loading amount of penicillin polymer shall be accurately weighed and appropriately measured according to the method of penicillin sodium and calculated by the external standard method based on penicillin peak volume, the amount of penicillin polymer should not exceed 0.10% of the labeled amount.
weight loss on drying this product, drying at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
insoluble particles this product is taken, and the labeled amount is added to the particle inspection water to make a solution containing 50mg per 1 ml, which is inspected according to law (General rule 0903), and the labeled amount is l. The conversion below Og is per l. In the Og sample, the particles containing l0um and 10um or more shall not exceed 6000 particles, and the particles containing 25um and 25um or more shall not exceed 600 particles.
the pH value, related substances, bacterial endotoxin and sterility shall be checked according to the method under the item of penicillin sodium, and shall be in accordance with the regulations.
others should comply with the relevant provisions under injection (General 0102).

Content determination

The content under the item of loading amount difference was accurately weighed and an appropriate amount was measured according to the method of penicillin potassium. Each 1 mg of C16H17KN204S is equivalent to 1598 penicillin units.

specification

According to C16H17KN204S (1)0.l25g (200,000 units)(2)0.25g (400,000 units) (3)0.5g (800,000 units) (4)0.625g(1 million units)

storage

sealed and stored in a cool, dark and dry place.

Last Update：2022-01-01 13:33:05

JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.

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CAS: 113-98-4
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CAS: 113-98-4
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Product Name: Penicillin G Potassium salt Visit Supplier Webpage Request for quotation
CAS: 113-98-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.

Spot supply

Product Name: Benzylpenicillin potassium Request for quotation
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685

Send QQ message

Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

Spot supply

Product Name: Benzylpenicillin Potassium Salt Visit Supplier Webpage Request for quotation
CAS: 113-98-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Hefei TNJ Chemical Industry Co.,Ltd.

Product Name: Benzylpenicillin potassium Request for quotation
CAS: 113-98-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840

Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog

Shanghai Yuanye Bio-Technology Co., Ltd.

Multiple SpecificationsSpot supply

Product Name: Penicillin G Potassium salt Visit Supplier Webpage Request for quotation
CAS: 113-98-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

Potassium benzylpenicillin

Raw Materials for Potassium benzylpenicillin

n-Butyl acetate
1-Butanol
Dextrose Anhydrate
Ethyl Alcohol
1-Butanol

Downstream Products for Potassium benzylpenicillin

6-Aminopenicillanic acid
procaine penicillin

Potassium benzylpenicillin

Benzylpenicillin potassium

CAS: 113-98-4

Molecular Formula: C16H17KN2O4S

Potassium benzylpenicillin - Names and Identifiers

Potassium benzylpenicillin - Physico-chemical Properties

Potassium benzylpenicillin - Risk and Safety